Magnesium for Atrial Fibrillation Rate Control in the ED

Today’s pearl is a continuation of Pearl 42: Medication Pearls for Atrial Fibrillation Management in the ED and reviews the role of magnesium for the treatment of atrial fibrillation.

Does magnesium reduce HR? How much and how fast to administer?

A summary of the studies using magnesium for atrial fibrillation (AF) rate control can be found in a 2016 ALiEM post. The most recent trial to evaluate magnesium for this indication is the LOMAGHI Study published in 2019. Our very own Dr. Jenny Koehl summarized it nicely.

Key teaching point: Magnesium sulfate for rapid AF needs to be administered over 10-20 minutes (rather than 1-2 hours) to achieve an effect.

Bottom Line: Magnesium seems to be safe and moderately effective for reducing heart rate in rapid AF. Even in the studies where magnesium was less effective than an active comparator, it still demonstrated some reduction in HR. Therefore, it seems reasonable to consider administering magnesium 2-4 gm IV as an adjunctive therapy while you are choosing between a calcium channel blocker or beta blocker as the primary rate-control agent. In some cases, you may find magnesium is enough to achieve lenient HR goals (ie, < 110 bpm). Monitor HR and BP appropriately.

Of note, magnesium is not mentioned in the 2014 AHA/ACC/HRS Guideline for the Management of Patients with Atrial Fibrillation.




Author: Bryan D. Hayes, PharmD

Attending Pharmacist, Emergency Medicine and Toxicology, Massachusetts General Hospital; Assistant Professor of EM, Harvard Medical School

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