Esmolol for Refractory VFib

Up until two years ago, beta blocker use for refractory ventricular fibrillation (VFib) had only been studied in animal models with sporadic human case reports. Two studies in humans have now been published and may provide some guidance in managing this difficult-to-treat condition.
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Blood Pressure Management in ICH: ATACH-2 Trial with a Focus on the Meds

Does intensive blood pressure control improve outcomes and reduce hematoma expansion in acute intracerebral hemorrhage (ICH)? The INTERACT-2 trial previously compared intensive vs. conservative blood pressure control in ICH patients and found no difference in death or disability between the two groups. Enter the ATACH-2 trial, published in the New England Journal of Medicine September 15, 2016. Dr. Ryan Radecki provides his review of the article on his EM Lit of Note site.

The purpose of this post is to evaluate the antihypertensive regimens used. Were they appropriate and are they applicable to practice everywhere?
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PCC Before Emergent LP

Although the true incidence of bleeding is unknown, there is likely an increased risk of spinal hematoma when performing a lumbar puncture (LP) in patients on vitamin K antagonists (eg, warfarin). A new study set out to determine the safety of prothrombin complex concentrate (PCC) when administered prior to emergent LP.

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